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BENEFICIAL EFFECTS OF GOJI BERRIES

A superfood that is an exellent source of natural antioxidants, vitamins and nutrients


Goji berries have been classified as a superfood and that is for very good reasons, because they contain:



- 18 amino acids, including the 8 essential ones

- Vitamin B-complex, A, C and E

- 21 trace minerals including copper, iron, zinc, magnesium, calcium, potassium and also selenium and germanium which are known anti-cancer agents

- 6 essential unsaturated fatty acids, like alpha-linoleic acid and linoleic acid

- a variety of phytochemicals and antioxidants including zeaxanthin, beta-carotene and other carotenoids, riboflavin, ascorbic acid, thiamine, nicotinic acid, lycopene, cryptoxanthin, lutein and xanthophyll

- 8 polysaccharides and 6 monosaccharides

- phenols that have antioxidant properties

- beta-sitosterol and other phytosterols which are anti-inflammatory agents that had been found to lower cholesterol, and has been used to treat impotence and prostate enlargement

Because goji berries are an abundent source of antioxidants that strenghten the immune system and protect the body from inflammation because they fight free radical damage. 


Relevant studies:


EYE PROTECTION


Goji berries protect the eyes from macular degeneration, one of the main causes of blindness, therefore are a very powerful treatment for this disease and are irrefutably beneficial for the vision due to their high levels of antioxidants, which stop the damaging of the retina from excessive exposure to UV light and other forms of oxidative stress.


This study found that daily dietary supplementation with goji berry for 90 days increases plasma zeaxanthin and antioxidant levels as well as protects from hypopigmentation and soft drusen accumulation in the macula of elderly subjects.




This human supplementation trial shows that zeaxanthin in whole goji berries is bioavailable and that intake of a modest daily amount markedly increases fasting plasma zeaxanthin levels, offering help in maintaining macular pigment density.

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The present study suggests that LBP (Lycium barbarum polysaccharide) may have a neuroprotective role to play in ocular diseases.

Two studies showing that the goji berry benefits eye health by protecting the retinal ganglion cells meaning that the antioxidants found in goji act as a natural treatment for glaucoma



Two more studies that prove the neuroprotective effects of goji on retina cells against ocular hypertension.


LIVER PROTECTION AND DETOXIFICATION


According to the traditional eastern medicines, goji berries are a very good source for liver protection.

Research showed that Betaine in the goji berries, after ingestion starts the production of Choline in the liver, which facilitates the detoxification process. It is also known to enhance memory, encourage muscle growth, protect DNA and against fatty liver disease.


LBP (Lycium barbarum polysaccharide) is effective in reducing necroinflammation and oxidative stress induced by a chemical toxin, thus it has a great potential use as a food supplement in the prevention of hepatic diseases.

Good news for people that like their alcoholic beverages - The results suggest that LBP (Lycium barbarum polysaccharide) is a promising agent to protect the liver from hepatotoxicity and fatty liver induced by ethanol intake.

KIDNEY PROTECTION


Also a good source for kidney protection agents, because goji berry helps the liver and kidney  to restore strength and vitality. It might help in getting rid of kidney stones and in cleansing the blood.

LBP (Lycium barbarum polysaccharide) improves the renal function and alleviates the inflammatory reaction in the kidneys of diabetic rabbits. In addition, the prevention effect of LBP is better than the treatment effect of LBP.



STABILIZING BLOOD SUGAR LEVELS AND HYPERTENSION


Goji berries help to control the amount of sugars that are reaching the bloodstream, which prevents the very unconfortable highs and lows caused by issues in balancing glucose levels. Goji berries exhibit significant hypoglycemic effects and insulin-sensitizing activity by increasing glucose responsiveness. Combined with a healthy diet, goji berries are a very good candidate for a natural diabetes remedy, without side effects and present an easy way to increase the insulin sensitivity of a person. Goji berries are the best choice for people having issues balancing their blood glucose levels and dealing with its unconvenient effects.


A study that shows the Hypoglycemic (blood sugar lowering) and hypolipidemic (lipid lowering) effects and antioxidant activity of fruit extracts from Lycium barbarum.


Another study showing the Hypoglycemic effect.



Lycium Barbarum fruit is able to modulate central nervous system reorganization, amplifying positive adaptive changes that improve functional recovery and promote selective target reinnervation in high fructose-diet rats with sciatic nerve crush-injury.

The results of this human study indicated a remarkable protective effect of LBP (Lycium barbarum polysaccharide) in patients with type 2 diabetes.


The results of this study showed that the increase of blood pressure in hypertension rats could be prevented significantly by treatment with 10% Lycium barbarum polysaccharide




STRENGHTENING THE IMMUNE SYSTEM

Goji berries provide an extremely high levels of antioxidants (like vitamin A and C),which constitute the basic building blocks of strenghtening the immune system to the point to be able to easily fend off colds, bacterial and viral infections as well as neurodegenerative diseases.

This study suggests that LBP (Lycium barbarum polysaccharide) has a highly significant effect on tumor weight and improves the immune system..

To examine the systematic effects of L. barbarum on immune function, general well-being, and safety, they tested the effects of a standardized L. barbarum fruit juice at 120 mL/day, equivalent to at least 150 g of fresh fruit, the amount traditionally used, for 30 days in a randomized, double-blind, placebo-controlled clinical study in 60 older healthy adults (55-72 years old). The group showed a significant increase in general feelings of well-being and showed a tendency for increased short-term memory and focus between pre- and post-intervention. In conclusion, daily consumption of Goji juice significantly increased several immunological responses and subjective feelings of general well-being without any adverse reactions.

The study population included 50 healthy adults aged 55 to 72 years. The results indicate that Goji juice increased antioxidant efficacies in humans by stimulating endogenous factors and suggest that continued use beyond 30 days might help prevent or reduce free radical-related conditions.

MAINTANING A HEALTHY SKIN


Goji berries are THE best source of beta-carotene, that helps promote healthy skin and is a strong candidate for a natural skin cancer treatment. The seeds of the goji berries contain 6 essential unsaturated fatty acids, like alpha-linoleic acid and linoleic acid, vital for a healthy skin.


This study showed that mice drinking 5% goji berry juice (Lycium barbarum) are protected from UV radiation-induced skin damage and offers protection against skin disorders. Furthermore, two known inducible endogenous skin antioxidants, haem oxygenase-1 and metallothionein, were found to be involved in the photoimmune protection. The results suggest that consumption of the goji berry juice could provide additional photoprotection for susceptible humans.

BOOSTS FERTILITY, TREATS INFERTILITY AND PROTECTS REPRODUCTIVE ORGANS 


According to the traditional eastern medicines of Tibet and China, goji berry consumption greatly benefits the reproductive system and the goji berries are used to increase fertility by boosting the vitality of the sperm and their number. Due to it's feminine "yin" aspect, goji berry is used to treat infertility in female patients with premature ovarian failure and the inability for normal ovulation.


This study done on rats, shows that goji berries protect against testicular tissue damage induced by heat exposure, raise antioxidant activity of superoxide dismutase in the reproductive system, raise sexual hormone levels and protect against DNA oxidative damage to testicular cells, providing support to the eastern traditional medicine claims of treating infertility. The present findings support the folk reputation of L. barbarum fruits as an aphrodisiac and fertility-facilitating agent, and provide scientific evidence for a basis for the extensive use of L. barbarum fruits as a traditional remedy for male infertility in China.


In this study they irradiated testicles with radioactive Cobalt, destroying their ability to reproduce and after treated them with LBP (Lycium barbarum polysaccharides) which had significant protective effects against damage, allowing rats to achieve near-complete recovery with LBP treatment !!! Pretty amazing!


Another study on rats that demonstrates the pro-sexual effect of LBP on normal and sexually-inhibited rats, and LBP may modulate sexual behavior by regulating neurogenesis.



BOOSTS ENERGY LEVELS AND IMPROVES MOOD

This was the first study on humans, reported from outside China that has examined the general effects of the orally consumed goji berry, Lycium barbarum, as a standardized juice. These results clearly indicate that daily consumption of Goji berry juice for 14 days increases subjective feelings of general well-being and energy levels and improves neurologic/psychologic performance and gastrointestinal functions, validating one more time the claims of the eastern traditional medicines of increasing energy levels, moods and digestive health, this time in human subjects.

Lycium barbarum Fruit (Goji) Attenuates the Adrenal Steroid Response to an Exercise Challenge and the Feeling of Tiredness: A Randomized, Double-blind, Placebo-controlled Human Clinical Study 

Yet another study done on humans shows that Lycium barbarum consumption attenuates the

adrenal steroid response and reduces the feeling of tiredness.


 L. barbarum polysaccharides administration can significantly decrease the oxidative stress induced by the exhaustive exercise.


This study found that the polysaccharide significantly enhanced muscle performance, enabling muscles to recover more quickly after strenuous activity and perform better all around.




IMPROVES MEMORY, MENTAL HEALTH, POST-TRAUMATIC RECOVERY

In this study rats were treated with scopolamine (a substance that completely erases short term memory for the time being that the subjects are under it's influence), and showed that the sugars found in the goji berries reversed the effects of scopolamine through it's antioxidative properties, protected the newborn neurons and protected from impairment of the working memory.

This study revealed that LBP treatment might effectively improve the traumatic cognition defect induced by severe stress (PTSD) and be useful for the intrusive memory-related cognition recovery.



INCREASES METABOLISM HELPS WITH WEIGHT LOSS


This study shows that L. barbarum consumption increases metabolic rate and reduces the waist circumference, relative to placebo treated control subjects.



ANTI-AGING EFFECTS

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NEUROPROTECTION, ALTZHEIMER's DISEASE

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This study shows the neuroprotective effects of the extract from L. barbarum. Study on anti-aging herbal medicine like L. barbarum may open a new therapeutic window for the prevention of Altzheimer's Disease.

Another study that shows that LBP from Fructus lycii is a potential neuroprotective agent in Altzheimer's Disease.

Polysaccharides from wolfberry antagonizes glutamate excitotoxicity in rat cortical neurons

Two more studies from the Journal of Alzheimer's disease, showing the neuroprotective effect of goji against Altzheimer's.


The results suggested that use of goji berries can open up a new avenue for drug discovery in neurodegenerative diseases.



PROTECTION FROM IONIZING RADIATION

LBP (Lycium barbarum polysaccharide) showed a protective effect on bone marrow against ionizing radiation and oxidative damage.



Study mentioned already above, showing significant protective effects against radiation damage.



PREVENTING AND CURING CANCER?? THE SKY IS THE LIMIT! 

Of the antioxidants present among goji berry benefits, carotenoids like zeaxanthin and precursors to vitamin C are the most extensively researched. High levels of these compounds give gojis a reputation for battling cancerous cells, fighting tumor growth, decreasing inflammatory cytokine levels and detoxifying the body of harmful toxins.

Goji berry benefits also extend to other parts of the body thanks to their polysaccharides and glycoconjugate compounds that promote unique bioactive immunomodulating, anti-tumor and antioxidant activities in the brain, liver, reproductive organs and digestive tract. Gojis are reported to have anti-aging properties and show anti-tumor activities against various types of skin cancer cells by inhibiting tumor growth and inducing apoptosis. 

Lycium barbarum polysaccharides induce apoptosis in human prostate cancer cells and inhibits prostate cancer growth in a xenograft mouse model of human prostate cancer.


This is one of the first studies to focus on LBP-induced interruption of the cell cycle in human colon carcinoma cells. The results suggest that LBP is a candidate anticancer agent.


The results of this study suggest that the L. barbarum fruit may be a potential dietary supplement and anticancer agent aimed at the prevention and treatment of cervical cancer

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This study suggests that LBP has a highly significant effect on tumor weight and improves the immune system.


The results suggest that LBP may induce immune responses and possess potential therapeutic efficacy in cancer therapy

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Seventy nine advanced cancer patients in a clinical trial were treated with LAK/IL-2 combining with Lycium Barbarum polysaccharides (LBP). Initial results of the treatment from 75 evaluable patients indicated that objective regression of cancer was achieved in patients with malignant melanoma, renal cell carcinoma, colorectal carcinoma, lung cancer, nasopharyngeal carcinoma, malignant hydrothorax. The results indicate that LBP can be used as an adjuvant in the biotherapy of cancer.


Radiosensitizing effects (becoming more sensitive to radiation treatment) of the Lycium barbarum polysaccharide (LBP) were observed in mice with lung cancer.


The anticancer activity of ethanol extract isolated from Goji berry (EEGB) on T47D human breast cancer cell line has been reported. Anticancer activity and lack of toxicity against normal cells indicate a chemopreventive potential of Goji berries in breast cancer treatment.


The results showed that LBP can be provided as a potential chemotherapeutic agent drug to treat cancer.


The goji berries major active ingredients, L. barbarum polysaccharides (LBP), scopoletin and 2-O-β-D-glucopyranosyl-L-ascorbic acid (AA-2βG), are found to have apoptotic and antiproliferative effects on cancer cell lines. Moreover, LBP also contributes to body's immunomodulatory effects and enhances effects of other cancer therapies.


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